Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 12/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9196053 | 0.91 | ALDH1A1 (0.44) | P2RX3HPGD | |
| SCHEMBL9202880 | 0.90 | P2RX3 (0.49) | P2RX3 | |
| SCHEMBL10557407 | 0.89 | MEN1 (0.47) | P2RX3TP53THRBMEN1KMT2A | |
| SCHEMBL9202886 | 0.84 | ALDH1A1 (0.38) | P2RX3MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9196436 | 0.82 | P2RX3 (0.44) | P2RX3TP53THRBMAPTLMNA | |
| SCHEMBL10560072 | 0.82 | P2RX3 (0.45) | P2RX3TP53THRBMAPTLMNA | |
| SCHEMBL9195065 | 0.82 | ALDH1A1 (0.43) | P2RX3TP53THRBMEN1KMT2A | |
| SCHEMBL10333434 | 0.80 | KDM4E (0.39) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL10559207 | 0.79 | P2RX3 (0.49) | P2RX3 | |
| SCHEMBL10559101 | 0.78 | P2RX3 (0.47) | P2RX3TP53THRBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383465-B1 | Tricyclic fused pyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-05-03 | — | — | EP | disclosed |
| US-5032594-A | Adenosine antagonist | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-07-16 | — | — | US | disclosed |
| EP-0383465-A2 | Tricyclic fused pyrimidine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-08-22 | — | — | EP | disclosed |