Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 2/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | RGS4 | P49798 | 2/20 | 0.41 |
| ▸ | RGS8 | P57771 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL325735 | 0.88 | MAPT (0.51) | ALDH1A1MAPTKDM4EALOX15CMA1 | |
| SCHEMBL23679701 | 0.87 | MAPT (0.47) | PROKR1ALDH1A1MAPTKDM4EALOX15 | |
| SCHEMBL10558278 | 0.83 | PROKR1 (0.49) | PROKR1ADORA3ALDH1A1MAPTKDM4E | |
| SCHEMBL320830 | 0.83 | RGS4 (0.53) | ADORA3ALDH1A1MAPTKDM4EALOX15 | |
| SCHEMBL4847620 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4EALOX15CMA1 | |
| SCHEMBL19073410 | 0.79 | MAPT (0.47) | ALDH1A1MAPTKDM4EALOX15CMA1 | |
| SCHEMBL19073042 | 0.79 | P2RX3 (0.47) | ALDH1A1MAPTKDM4EALOX15CMA1 | |
| SCHEMBL10502022 | 0.77 | ADORA2A (0.44) | ALDH1A1RGS4RGS8GSK3B | |
| SCHEMBL19147820 | 0.76 | KAT2B (0.47) | ALDH1A1ALOX15 | |
| SCHEMBL31213513 | 0.75 | HPGD (0.52) | ADORA3MAPTMEN1KMT2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824848-A | TREATMENT, PREVENTION OF NERVOUS SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0237289-A2 | Pyrazolo [3,4-d] pyrimidine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-09-16 | — | — | EP | disclosed |