Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.45 |
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 10/20 | 0.45 |
| ▸ | HTR2A | P28223 | 8/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.45 |
| ▸ | HRH1 | P35367 | 7/20 | 0.45 |
| ▸ | HTR6 | P50406 | 7/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.45 |
| ▸ | DRD4 | P21917 | 6/20 | 0.45 |
| ▸ | DRD5 | P21918 | 6/20 | 0.45 |
| ▸ | HRH2 | P25021 | 6/20 | 0.45 |
| ▸ | HTR7 | P34969 | 6/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 5/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10692175 | 0.95 | DRD3 (0.45) | DRD3HTR2ASLC6A3OPRK1HRH1 | |
| Oxalic Acid SCHEMBL10691411 | 0.78 | HTR2A (0.46) | HTR2AOPRM1HTR6HTR7HTR1A | |
| Oxalic Acid SCHEMBL10806817 | 0.74 | CCR1 (0.49) | DRD3HTR2ASLC6A3OPRK1HRH1 | |
| Oxalic Acid SCHEMBL11016213 | 0.74 | HTR2A (0.44) | DRD3HTR2ASLC6A3OPRK1HRH1 | |
| SCHEMBL10558080 | 0.72 | HSD11B1 (0.43) | CYP3A4CYP2D6MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4229226 | 0.72 | SIGMAR1 (0.56) | DRD3HTR2ASLC6A3OPRK1HRH1 | |
| SCHEMBL4379525 | 0.71 | DRD3 (0.58) | DRD3HTR2ASLC6A3OPRK1HRH1 | |
| SCHEMBL9666472 | 0.71 | HTR2A (0.47) | DRD3HTR2ASLC6A3OPRK1HRH1 | |
| SCHEMBL195048 | 0.71 | DRD3 (0.46) | DRD3HTR2ASLC6A3OPRK1HRH1 | |
| SCHEMBL10691217 | 0.70 | HTR2A (0.47) | HTR2AOPRM1HTR6HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4810792-A | HYPOTENSIVE AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1989-03-07 | — | — | US | disclosed |
| US-4788201-A | HYPOTENSIVE AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-11-29 | — | — | US | disclosed |