Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 2/20 | 0.62 |
| ▸ | TDP2 | O95551 | 2/20 | 0.62 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.62 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 2/20 | 0.56 |
| ▸ | GALK1 | P51570 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | APAF1 | O14727 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.56 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10558121 | 0.84 | KMT2A (0.66) | NSD2TDP2PLA2G1BATG4BPOLB | |
| SCHEMBL10723724 | 0.81 | CHRM4 (0.64) | POLBKMT2AMAPTCHRM4ALDH1A1 | |
| SCHEMBL2961026 | 0.79 | CHRM4 (0.62) | KMT2AMAPTCHRM4ALDH1A1SMN1; SMN2 | |
| SCHEMBL8568869 | 0.78 | NSD2 (0.73) | NSD2TDP2PLA2G1BATG4BPOLB | |
| SCHEMBL3223553 | 0.77 | CHRM4 (0.61) | MAPTCHRM4ALDH1A1MAPK1GBA1 | |
| SCHEMBL2962429 | 0.77 | MEN1 (0.62) | KMT2ACHRM4ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8651868 | 0.77 | NSD2 (1.00) | NSD2TDP2PLA2G1BATG4BPOLB | |
| SCHEMBL17249912 | 0.77 | NSD2 (0.71) | NSD2TDP2PLA2G1BATG4BPOLB | |
| SCHEMBL10446114 | 0.77 | NSD2 (0.71) | NSD2TDP2PLA2G1BATG4BPOLB | |
| SCHEMBL2953603 | 0.75 | MAPT (0.59) | KMT2AMAPTCHRM4ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4829089-A | ANTIINFLAMMATORY, BRONCHODILATOR | AMERICAN CYANAMID COMPANY (US) | 1989-05-09 | — | — | US | disclosed |
| US-4771061-A | Substituted piperazine-1,4-naphthalenediones useful for treating asthma, allergic diseases and/or inflammation | AMERICAN CYANAMID COMPANY (US) | 1988-09-13 | — | — | US | disclosed |
| US-4686220-A | Substituted 2-[b-substituted-amino)-ethylamino]-1,4-naphthalenediones for treating asthma, allergic diseases and inflammation in warm-blooded animals | AMERICAN CYANAMID COMPANY (US) | 1987-08-11 | — | — | US | disclosed |
| EP-0226842-A2 | Substituted 1,4-naphthalenediones, processes for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1987-07-01 | — | — | EP | disclosed |