Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9197469 | 0.85 | HPGD (0.51) | KMT2AMEN1CYP3A4ADORA2AADORA1 | |
| SCHEMBL10501681 | 0.80 | ALDH1A1 (0.41) | ALDH1A1CYP1A2CYP3A4ADORA2AADORA2B | |
| SCHEMBL10559101 | 0.80 | P2RX3 (0.47) | LMNAADORA2AADORA2BADORA1P2RX3 | |
| SCHEMBL9202886 | 0.78 | ALDH1A1 (0.38) | KMT2AMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL10560334 | 0.78 | P2RX3 (0.43) | ADORA2BP2RX3 | |
| SCHEMBL10564399 | 0.78 | RGS4 (0.44) | KMT2AMEN1ALDH1A1LMNAP2RX3 | |
| SCHEMBL10559533 | 0.78 | P2RX3 (0.42) | P2RX3 | |
| SCHEMBL10561004 | 0.78 | HPGD (0.49) | KMT2AMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL9202879 | 0.77 | ALDH1A1 (0.38) | KMT2AMEN1ALDH1A1DPP4CYP1A2 | |
| SCHEMBL10562415 | 0.76 | TAAR1 (0.45) | KMT2AMEN1ALDH1A1LMNAADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824848-A | TREATMENT, PREVENTION OF NERVOUS SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0237289-A2 | Pyrazolo [3,4-d] pyrimidine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-09-16 | — | — | EP | disclosed |