Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10557480 | 0.93 | TLR8 (0.38) | TLR8TLR7BCHEACHEHPGD | |
| SCHEMBL10561004 | 0.83 | HPGD (0.49) | ADRA2ABCHEACHEL3MBTL1ALDH1A1 | |
| SCHEMBL10560450 | 0.80 | GSK3B (0.45) | ADRA2ABCHEACHEL3MBTL1ALDH1A1 | |
| SCHEMBL10332847 | 0.79 | CYP1A2 (0.42) | ADRA2AL3MBTL1ALDH1A1GAAMAPT | |
| SCHEMBL10562415 | 0.77 | TAAR1 (0.45) | L3MBTL1ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL9197469 | 0.76 | HPGD (0.51) | HPGDADORA3 | |
| SCHEMBL10501681 | 0.73 | ALDH1A1 (0.41) | ALDH1A1GAAMAPTPDE4APDE4B | |
| SCHEMBL10559972 | 0.73 | ADRA2A (0.47) | ADRA2A | |
| SCHEMBL6446786 | 0.70 | CYP3A4 (0.68) | ADRA2ABCHEACHEL3MBTL1ALDH1A1 | |
| SCHEMBL10992886 | 0.68 | CYP1A2 (0.51) | ADRA2AL3MBTL1ALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824848-A | TREATMENT, PREVENTION OF NERVOUS SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0237289-A2 | Pyrazolo [3,4-d] pyrimidine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-09-16 | — | — | EP | disclosed |