Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10565633 | 1.00 | CHRNA7 (0.35) | CHRNA7LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL10565612 | 0.77 | CHRM2 (0.51) | LMNACHRM2CHRM4CHRM5THRB | |
| SCHEMBL10563679 | 0.77 | CHRM2 (0.51) | LMNACHRM2CHRM4CHRM5THRB | |
| SCHEMBL15592768 | 0.75 | LMNA (0.39) | LMNACHRM2CHRM4CHRM5THRB | |
| SCHEMBL10565738 | 0.72 | CHRNB2 (0.37) | LMNACHRNB2CHRNA4 | |
| SCHEMBL10562984 | 0.69 | HTR2A (0.32) | LMNA | |
| SCHEMBL10562477 | 0.68 | HDAC3 (0.34) | CHRNB2CHRNA4 | |
| SCHEMBL10226100 | 0.67 | PTPN1 (0.35) | CHRNA7LMNA | |
| SCHEMBL9594631 | 0.66 | SIGMAR1 (0.43) | LMNA | |
| SCHEMBL24733231 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4798841-A | COGNITION ACTIVATORS, ANALGESICS | WARNER-LAMBERT COMPANY (US) | 1989-01-17 | — | — | US | disclosed |
| EP-0291673-A1 | Tetrahydropyridine oximes, a process for their preparation and use thereof as cholinergic agents | WARNER-LAMBERT COMPANY (US) | 1988-11-23 | — | — | EP | disclosed |