SCHEMBL10565752

SCHEMBL10565752

Cc1nc(C)nc(NC(=O)NS(=O)(=O)c2ccccc2S(=O)(=O)C(C)C)n1

nearest known ligand 0.57

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.43
NPC1 O15118 1/20 0.43
ALDH1A1 P00352 1/20 0.43
MAPT P10636 1/20 0.41
FBP1 P09467 1/20 0.40
CA12 O43570 2/20 0.40
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA9 Q16790 2/20 0.40
LMNA P02545 1/20 0.37
GAA P10253 1/20 0.37
NLRP3 Q96P20 1/20 0.36
INSR P06213 1/20 0.36
ALK Q9UM73 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10570983 0.90 ALDH1A1 (0.45) KDM4ENPC1ALDH1A1MAPTFBP1
SCHEMBL10568164 0.89 GAA (0.46) KDM4ENPC1ALDH1A1MAPTFBP1
SCHEMBL10934357 0.87 KDM4E (0.39) KDM4ENPC1ALDH1A1MAPTFBP1
SCHEMBL10569605 0.84 ALDH1A1 (0.47) KDM4ENPC1ALDH1A1MAPTFBP1
SCHEMBL11637413 0.84 FBP1 (0.55) KDM4ENPC1ALDH1A1MAPTFBP1
SCHEMBL10568292 0.83 GAA (0.58) KDM4ENPC1ALDH1A1MAPTGAA
SCHEMBL10888753 0.83 KDM4E (0.45) KDM4ENPC1ALDH1A1MAPTFBP1
SCHEMBL11086424 0.82 NPC1 (0.43) KDM4ENPC1ALDH1A1MAPTFBP1
SCHEMBL10569768 0.82 GAA (0.51) KDM4ENPC1ALDH1A1MAPTGAA
SCHEMBL13875491 0.82 KDM4E (0.44) KDM4ENPC1ALDH1A1MAPTFBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0035893-B1 HERBICIDAL BENZENE- AND PYRIDINE-SULFONAMIDE DERIVATIVES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1985-11-21 EP claimed
EP-0035893-A2 Herbicidal benzene- and pyridine-sulfonamide derivatives E.I. DU PONT DE NEMOURS AND COMPANY (US) 1981-09-16 EP claimed
US-4818277-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-04-04 US disclosed
EP-0035893-B1 HERBICIDAL BENZENE- AND PYRIDINE-SULFONAMIDE DERIVATIVES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1985-11-21 EP disclosed
EP-0035893-A2 Herbicidal benzene- and pyridine-sulfonamide derivatives E.I. DU PONT DE NEMOURS AND COMPANY (US) 1981-09-16 EP disclosed