SCHEMBL10568164

SCHEMBL10568164

Cc1cc(C)nc(NC(=O)NS(=O)(=O)c2ccccc2S(=O)(=O)C(C)C)n1

nearest known ligand 0.65

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.46
LMNA P02545 2/20 0.45
ALOX15 P16050 1/20 0.44
ALDH1A1 P00352 2/20 0.43
TSHR P16473 2/20 0.43
KDM4E B2RXH2 1/20 0.42
NPC1 O15118 1/20 0.42
MAPT P10636 1/20 0.41
CAMK2D Q13557 1/20 0.40
FBP1 P09467 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10569768 0.90 GAA (0.51) GAAALDH1A1TSHRKDM4ENPC1
SCHEMBL10565752 0.89 KDM4E (0.43) GAALMNAALDH1A1KDM4ENPC1
SCHEMBL11094019 0.86 GAA (0.49) GAALMNAALOX15ALDH1A1TSHR
SCHEMBL10650821 0.86 GAA (0.49) GAALMNAALOX15ALDH1A1TSHR
SCHEMBL27846320 0.86 GAA (0.49) GAALMNAALOX15ALDH1A1TSHR
SCHEMBL10568292 0.84 GAA (0.58) GAAALDH1A1KDM4ENPC1MAPT
SCHEMBL11326475 0.84 FBP1 (0.54) GAALMNAALOX15ALDH1A1TSHR
SCHEMBL11326481 0.84 FBP1 (0.54) GAALMNAALOX15ALDH1A1TSHR
SCHEMBL9805001 0.83 GAA (0.49) GAALMNAALOX15ALDH1A1TSHR
SCHEMBL10569605 0.83 ALDH1A1 (0.47) GAAALDH1A1KDM4ENPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0035893-B1 HERBICIDAL BENZENE- AND PYRIDINE-SULFONAMIDE DERIVATIVES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1985-11-21 EP claimed
EP-0035893-A2 Herbicidal benzene- and pyridine-sulfonamide derivatives E.I. DU PONT DE NEMOURS AND COMPANY (US) 1981-09-16 EP claimed
US-4818277-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-04-04 US disclosed
EP-0035893-B1 HERBICIDAL BENZENE- AND PYRIDINE-SULFONAMIDE DERIVATIVES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1985-11-21 EP disclosed
EP-0035893-A2 Herbicidal benzene- and pyridine-sulfonamide derivatives E.I. DU PONT DE NEMOURS AND COMPANY (US) 1981-09-16 EP disclosed