Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10568156 | 0.84 | MAPT (0.36) | MAPTGAAALDH1A1KMT2ACYP2C9 | |
| SCHEMBL10563785 | 0.78 | PGR (0.36) | MAPTGAAPGRALDH1A1KMT2A | |
| SCHEMBL9831073 | 0.74 | HCAR3 (0.42) | MAPTGAAKCNMA1PGRALDH1A1 | |
| SCHEMBL9833518 | 0.71 | MAPT (0.56) | MAPTKCNMA1ALDH1A1KMT2AMEN1 | |
| SCHEMBL9833049 | 0.67 | MAPT (0.41) | MAPTGAAKCNMA1ALDH1A1KMT2A | |
| SCHEMBL9833818 | 0.67 | MAPT (0.42) | MAPTGAAKCNMA1ALDH1A1KMT2A | |
| SCHEMBL9831111 | 0.67 | PGR (0.48) | MAPTPGRALDH1A1KMT2AMEN1 | |
| SCHEMBL9834129 | 0.66 | AURKB (0.44) | MAPTGAAKMT2AMEN1NPC1 | |
| SCHEMBL9831885 | 0.65 | MAPT (0.43) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL10567315 | 0.65 | MAPT (0.37) | MAPTGAAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4835280-A | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| US-4695567-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-09-22 | — | — | US | disclosed |
| EP-0189103-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1986-07-30 | — | — | EP | disclosed |