Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDXK | O00764 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10563076 | 0.80 | LMNA (0.30) | SMN1; SMN2 | |
| SCHEMBL10563083 | 0.79 | — | — | |
| SCHEMBL10564142 | 0.76 | KMT2A (0.43) | MEN1GAAMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL10568325 | 0.69 | MEN1 (0.32) | PDXKMEN1GAAMAPTRAB9A | |
| SCHEMBL10510198 | 0.64 | GAA (0.33) | MEN1GAARAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL16102904 | 0.59 | HTT (0.51) | PDXKMEN1GAAMAPTRAB9A | |
| SCHEMBL15307200 | 0.59 | HPGD (0.48) | MEN1GAAMAPTRAB9AKMT2A | |
| SCHEMBL15307199 | 0.58 | HPGD (0.39) | MEN1GAAMAPTRAB9AKMT2A | |
| SCHEMBL9296106 | 0.56 | KDM4E (0.47) | MEN1GAAMAPTRAB9AKMT2A | |
| SCHEMBL5463526 | 0.56 | KMT2A (0.54) | MEN1GAAMAPTRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4837238-A | Pharmacologically useful pyrazolopyridines | BEECHAM GROUP P.L.C. (GB) | 1989-06-06 | — | — | US | claimed |
| EP-0193329-A2 | Pyrazolopyridines, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1986-09-03 | — | — | EP | claimed |
| US-4837238-A | Pharmacologically useful pyrazolopyridines | BEECHAM GROUP P.L.C. (GB) | 1989-06-06 | — | — | US | disclosed |