Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10566312 | 0.80 | PDXK (0.31) | SMN1; SMN2 | |
| SCHEMBL10565128 | 0.80 | KMT2A (0.39) | LMNASMN1; SMN2JAK2JAK1JAK3 | |
| SCHEMBL10563083 | 0.77 | — | — | |
| SCHEMBL10568325 | 0.64 | MEN1 (0.32) | LMNASMN1; SMN2 | |
| SCHEMBL10564142 | 0.61 | KMT2A (0.43) | LMNASMN1; SMN2 | |
| SCHEMBL31727858 | 0.56 | — | — | |
| SCHEMBL16102904 | 0.55 | HTT (0.51) | LMNASMN1; SMN2JAK2JAK1JAK3 | |
| SCHEMBL5463526 | 0.51 | KMT2A (0.54) | LMNASMN1; SMN2 | |
| SCHEMBL11179411 | 0.49 | KDM4E (0.51) | LMNA | |
| SCHEMBL11450535 | 0.49 | KDM4E (0.49) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4837238-A | Pharmacologically useful pyrazolopyridines | BEECHAM GROUP P.L.C. (GB) | 1989-06-06 | — | — | US | disclosed |
| EP-0193329-A2 | Pyrazolopyridines, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1986-09-03 | — | — | EP | disclosed |