Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 2/20 | 0.45 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10566942 | 0.71 | HRH3 (0.49) | BRS3PDE10ADAOHRH3 | |
| SCHEMBL28770122 | 0.70 | PDE10A (0.66) | BRS3PDE10A | |
| SCHEMBL10565636 | 0.68 | HRH3 (0.53) | PDE10ADAOHRH3 | |
| SCHEMBL12522164 | 0.68 | BRS3 (0.51) | BRS3DAOHRH3 | |
| SCHEMBL58872 | 0.68 | SIGMAR1 (0.54) | — | |
| SCHEMBL470 | 0.67 | — | — | |
| SCHEMBL54347 | 0.67 | HTR2A (0.70) | — | |
| SCHEMBL23812457 | 0.67 | AOC3 (0.67) | DAOHRH3 | |
| SCHEMBL8957090 | 0.67 | HRH1 (0.62) | BRS3PDE10AHTR1BHRH1MTOR | |
| SCHEMBL4654157 | 0.66 | SIGMAR1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659182-A1 | PIPERAZINE DERIVATIVES AND SALTS THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-06-28 | — | — | EP | disclosed |
| WO-1995002593-A1 | PIPERAZINE DERIVATIVES AND SALTS THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-01-26 | — | — | WO | disclosed |