Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.69 |
| ▸ | NPC1 | O15118 | 4/20 | 0.69 |
| ▸ | RAB9A | P51151 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | PKM | P14618 | 2/20 | 0.69 |
| ▸ | P4HB | P07237 | 1/20 | 0.65 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.65 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22014376 | 1.00 | MAPT (0.69) | MAPTKDM4ENPC1RAB9ALMNA | |
| SCHEMBL10376888 | 0.83 | HSP90AA1 (0.55) | MAPTKDM4ENPC1RAB9ALMNA | |
| SCHEMBL10376889 | 0.83 | HSP90AA1 (0.55) | MAPTKDM4ENPC1RAB9ALMNA | |
| Pyrazinamide SCHEMBL28973464 | 0.82 | ADORA3 (0.60) | MAPTKDM4ENPC1RAB9ALMNA | |
| SCHEMBL977480 | 0.81 | MAPT (1.00) | MAPTKDM4ENPC1RAB9ALMNA | |
| SCHEMBL4400320 | 0.81 | MAPT (1.00) | MAPTKDM4ENPC1RAB9ALMNA | |
| SCHEMBL3595621 | 0.80 | BCHE (0.54) | MAPTKDM4ENPC1RAB9ALMNA | |
| SCHEMBL3595625 | 0.80 | BCHE (0.54) | MAPTKDM4ENPC1RAB9ALMNA | |
| SCHEMBL13381516 | 0.80 | KDM4E (0.78) | MAPTKDM4ENPC1RAB9ALMNA | |
| SCHEMBL979408 | 0.79 | CYP1B1 (1.00) | MAPTLMNACYP1B1CYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4831034-A | 4-benzylpiperazines useful as neuroleptics | RHONE-POULENC SANTE (FR) | 1989-05-16 | — | — | US | disclosed |