SCHEMBL4400320

SCHEMBL4400320

O=C(/C=C/c1ccccc1)c1ccccn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 1.00
RAB9A P51151 6/20 1.00
NPC1 O15118 5/20 1.00
PKM P14618 5/20 1.00
LMNA P02545 5/20 1.00
KDM4E B2RXH2 3/20 1.00
KMT2A Q03164 4/20 0.70
L3MBTL1 Q9Y468 3/20 0.70
MEN1 O00255 2/20 0.70
ALDH1A1 P00352 2/20 0.70
PLIN1 O60240 3/20 0.61
PLIN5 Q00G26 3/20 0.61
ABHD5 Q8WTS1 3/20 0.61
CYP1B1 Q16678 2/20 0.61
RECQL P46063 2/20 0.61
BCHE P06276 1/20 0.61
TNFRSF1A P19438 1/20 0.61
ACHE P22303 1/20 0.61
MAOB P27338 1/20 0.61
KRAS P01116 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL977480 1.00 MAPT (1.00) MAPTRAB9ANPC1PKMLMNA
SCHEMBL12257967 0.95 MAPT (0.90) MAPTRAB9ANPC1PKMLMNA
SCHEMBL1929871 0.90 PKM (0.82) MAPTRAB9ANPC1PKMLMNA
SCHEMBL1929873 0.90 PKM (0.82) MAPTRAB9ANPC1PKMLMNA
SCHEMBL9221198 0.90 NPC1 (0.81) MAPTRAB9ANPC1PKMLMNA
SCHEMBL9221208 0.90 NPC1 (0.81) MAPTRAB9ANPC1PKMLMNA
SCHEMBL1604280 0.88 MAPT (0.79) MAPTRAB9ANPC1PKMLMNA
SCHEMBL31436352 0.88 MAPT (0.79) MAPTRAB9ANPC1PKMLMNA
SCHEMBL9231011 0.87 MAPT (0.77) MAPTRAB9ANPC1PKMLMNA
SCHEMBL6793181 0.87 RAB9A (0.77) MAPTRAB9ANPC1PKMLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060074108-A1 Matrix metalloprotease (MMP) inhibitors and their application in cosmetic and pharmaceutical composition BIODERM RESEARCH (US) 2006-04-06 US claimed
JP-7126543-A None JP disclosed
CN-118638046-A Method for asymmetric synthesis of pyridine-2-formylnorbornene by rare earth catalysis 北京化工大学 2024-09-13 CN disclosed
US-12016312-B2 Animal models, screening methods, and treatment methods for intraocular diseases or disorders Smilebiotek Zhuhai Limited (CN) 2024-06-25 US disclosed
US-12016312-B2 Animal models, screening methods, and treatment methods for intraocular diseases or disorders Smilebiotek Zhuhai Limited (CN) 2024-06-25 US disclosed
CN-115814857-B Artificial metalloenzyme based on Nitrophorin2 protein scaffold and preparation method and application thereof 华南理工大学 2024-03-26 CN disclosed
CN-115814857-A Artificial metalloenzyme based on Nitrophorin2 protein scaffold and preparation method and application thereof 华南理工大学 2023-03-21 CN disclosed
CN-110756222-B Nucleoside triphosphate artificial metalloenzyme and preparation and application thereof 陕西师范大学 2022-08-23 CN disclosed
US-20220223795-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME LT MATERIALS CO., LTD. (KR) 2022-07-14 US disclosed
US-20220015338-A1 ANIMAL MODELS, SCREENING METHODS, AND TREATMENT METHODS FOR INTRAOCULAR DISEASES OR DISORDERS Smilebiotek Zhuhai Limited (CN) 2022-01-20 US disclosed
US-8168307-B2 Organic compound, charge transport material and organic electroluminescent device PIONEER CORPORATION (JP) 2012-05-01 US disclosed
US-8168307-B2 Organic compound, charge transport material and organic electroluminescent device PIONEER CORPORATION (JP) 2012-05-01 US disclosed
US-20090021146-A1 ORGANIC COMPOUND, CHARGE TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE PIONEER CORPORATION (JP) 2009-01-22 US disclosed
US-20090021146-A1 ORGANIC COMPOUND, CHARGE TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE PIONEER CORPORATION (JP) 2009-01-22 US disclosed
EP-1858094-A1 ORGANIC COMPOUND, CHARGE TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE Pioneer Corporation (JP) 2007-11-21 EP disclosed
US-7268250-B2 Process for producing optically active compound KANTO KAGAKU KABUSHIKI KAISHA (JP) 2007-09-11 US disclosed
US-7268250-B2 Process for producing optically active compound KANTO KAGAKU KABUSHIKI KAISHA (JP) 2007-09-11 US disclosed
EP-0677293-A1 PHARMACEUTICAL USE OF TERPYRIDINE DERIVATIVE TAISHO PHARMACEUTICAL CO. LTD (JP) 1995-10-18 EP disclosed
JP-H07126543-A INDOLIZINE COLOR AND METHOD FOR IMPROVING SOLUBILITY TDK CORP 1995-05-16 JP disclosed
US-4250324-A Water-degradable esters and process for the preparation thereof BEASLEY MARVIN L 1981-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090021146-A1 ORGANIC COMPOUND, CHARGE TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE SLC25A21, SLCO2A1, OCIAD2 MAPT 1949/4885RAB9A 1941/4885NPC1 712/4885
US-12016312-B2 Animal models, screening methods, and treatment methods for intraocular diseases or disorders MB, MYOC, PDE6A MAPT 2250/4885RAB9A 1921/4885NPC1 782/4885
US-20220223795-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME CRY1, CYP1A1, CYP1B1 MAPT 1857/4885RAB9A 2232/4885NPC1 2620/4885
US-20220015338-A1 ANIMAL MODELS, SCREENING METHODS, AND TREATMENT METHODS FOR INTRAOCULAR DISEASES OR DISORDERS MB, MYOC, PDE6A MAPT 2250/4885RAB9A 1921/4885NPC1 782/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.