Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.43 |
| ▸ | YTHDF2 | Q9Y5A9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10564706 | 0.88 | CRHR1 (0.46) | HPGDMAPTL3MBTL1LMNACRHR1 | |
| SCHEMBL10568473 | 0.83 | MEN1 (0.47) | HPGDMAPTLMNACRHR1ALDH1A1 | |
| SCHEMBL10568466 | 0.78 | ALDH1A1 (0.43) | HPGDLMNACRHR1ALDH1A1KDM4E | |
| SCHEMBL10566728 | 0.75 | MAPT (0.39) | MAPTL3MBTL1LMNACRHR1ALDH1A1 | |
| SCHEMBL10571998 | 0.73 | YTHDC1 (0.40) | YTHDC1YTHDF2MEN1KMT2ARAB9A | |
| SCHEMBL10569381 | 0.73 | CYP2C19 (0.51) | HPGDYTHDC1YTHDF2L3MBTL1ALDH1A1 | |
| SCHEMBL5358160 | 0.73 | ALDH1A1 (0.46) | HPGDYTHDC1YTHDF2MAPTL3MBTL1 | |
| SCHEMBL10567327 | 0.72 | YTHDC1 (0.41) | HPGDYTHDC1YTHDF2L3MBTL1LMNA | |
| SCHEMBL6851931 | 0.72 | MAPT (0.40) | MAPTL3MBTL1LMNACRHR1ALDH1A1 | |
| SCHEMBL10565223 | 0.72 | CHEK1 (0.41) | MAPTL3MBTL1LMNACRHR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4833136-A | ANTIINFLAMMATORY AGENTS | BEECHAM GROUP P.L.C. (GB) | 1989-05-23 | — | — | US | disclosed |
| EP-0239191-A2 | Pyrazolo[4,3-b]pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-09-30 | — | — | EP | disclosed |