Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295809 | 1.00 | MAPK8 (0.37) | MAPK8ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL10562070 | 0.72 | KMT2A (0.37) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7285751 | 0.72 | KMT2A (0.37) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL16943227 | 0.71 | KDM4E (0.62) | MAPK8SMN1; SMN2LMNAKDM4ERAB9A | |
| SCHEMBL19151419 | 0.70 | SMN1; SMN2 (0.53) | MAPK8SMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL24329605 | 0.69 | CHRNB2 (0.46) | KDM4EALDH1A1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL28530934 | 0.69 | SMN1; SMN2 (0.51) | MAPK8SMN1; SMN2LMNAKDM4ERAB9A | |
| SCHEMBL22937086 | 0.69 | CACNA1C (0.51) | MAPK8GRM5MEN1KMT2AHSD17B10 | |
| SCHEMBL10463823 | 0.67 | SMN1; SMN2 (0.63) | SMN1; SMN2KDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL7286157 | 0.66 | GRIN2D (0.32) | SMN1; SMN2RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863938-A | Pyridine derivatives and their use as nootropic agents | CIBA-GEIGY CORPORATION (US) | 1989-09-05 | — | — | US | claimed |
| US-4863938-A | Pyridine derivatives and their use as nootropic agents | CIBA-GEIGY CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |