SCHEMBL10567658

SCHEMBL10567658

O=C1CC(CI)C(=O)N1c1cc(C(F)(F)F)ccc1Cl

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ADRA1B P35368 1/20 0.42
MAT2A P31153 1/20 0.41
KMT2A Q03164 4/20 0.39
TRAP1 Q12931 1/20 0.39
MEN1 O00255 3/20 0.38
ALDH1A1 P00352 2/20 0.38
TSHR P16473 2/20 0.38
ATM Q13315 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
CDK4 P11802 1/20 0.37
CCND1 P24385 1/20 0.37
USP2 O75604 1/20 0.36
POLB P06746 1/20 0.36
CASP1 P29466 1/20 0.36
AADAT Q8N5Z0 1/20 0.36
CFTR P13569 1/20 0.36
SCD O00767 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10569404 0.90 ADRA1B (0.43) ADRA1BMAT2AKMT2ATRAP1MEN1
SCHEMBL10566829 0.89 ADRA1B (0.43) ADRA1BMAT2AKMT2ATRAP1MEN1
SCHEMBL10569778 0.84 ADRA1B (0.40) ADRA1BMAT2AKMT2ATRAP1MEN1
SCHEMBL10567509 0.83 ADRA1B (0.41) ADRA1BMAT2AKMT2ATRAP1MEN1
SCHEMBL10570593 0.82 ADRA1B (0.38) ADRA1BMAT2AKMT2ATRAP1MEN1
SCHEMBL10570567 0.81 MEN1 (0.54) KMT2AMEN1ALDH1A1POLB
SCHEMBL10567104 0.79 SLC6A2 (0.45) KMT2AMEN1ALDH1A1TSHRL3MBTL1
SCHEMBL10567245 0.78 MEN1 (0.39) KMT2AMEN1ALDH1A1L3MBTL1
SCHEMBL10576021 0.75 KMT2A (0.47) KMT2AMEN1ALDH1A1
SCHEMBL10567128 0.74 ALDH1A1 (0.54) KMT2AMEN1ALDH1A1TSHRAADAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4847285-A 1-substituted phenyl-3-substituted methyl-pyrrolidine-2,5-diones and plant fungicide compositions containing same THE DOW CHEMICAL COMPANY (US) 1989-07-11 US disclosed