Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12950188 | 0.84 | OPRM1 (0.53) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL20148097 | 0.83 | OPRM1 (0.51) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL26667116 | 0.83 | MEN1 (0.41) | OPRM1LMNAPOLBMAPK1MEN1 | |
| SCHEMBL980391 | 0.79 | OPRM1 (0.44) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL22907281 | 0.79 | OPRM1 (0.44) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL15232250 | 0.79 | OPRM1 (0.44) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL19325498 | 0.79 | OPRM1 (0.48) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL379072 | 0.79 | OPRM1 (0.48) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL26667143 | 0.78 | USP2 (0.41) | MEN1KMT2A | |
| SCHEMBL7313219 | 0.78 | GAA (0.38) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4804665-A | NERVOUS SYSTEM DISORDERS; COGNITION ACTIVATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-02-14 | — | — | US | disclosed |
| EP-0273659-A1 | Azaspiro compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1988-07-06 | — | — | EP | disclosed |