Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL380983 | 0.85 | GAA (0.48) | KMT2AL3MBTL1MGAMGAASI | |
| SCHEMBL1728632 | 0.83 | L3MBTL1 (0.39) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL15232250 | 0.82 | OPRM1 (0.44) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL980391 | 0.82 | OPRM1 (0.44) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL25447273 | 0.81 | CYP2C19 (0.36) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL8264963 | 0.81 | CYP2C19 (0.50) | KMT2AL3MBTL1MGAMGAASI | |
| SCHEMBL1186304 | 0.81 | CYP2C19 (0.46) | KMT2AL3MBTL1MGAMGAASI | |
| SCHEMBL14033377 | 0.80 | L3MBTL1 (0.37) | KMT2AL3MBTL1MGAMGAASI | |
| SCHEMBL867537 | 0.79 | CYP2C19 (0.53) | KMT2AL3MBTL1MGAMGAASI | |
| SCHEMBL10567693 | 0.79 | OPRM1 (0.49) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |