Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12950188 | 0.87 | OPRM1 (0.53) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL164041 | 0.85 | ALDH1A1 (0.40) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL10567693 | 0.83 | OPRM1 (0.49) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL19325498 | 0.81 | OPRM1 (0.48) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL379072 | 0.81 | OPRM1 (0.48) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL20069686 | 0.81 | L3MBTL1 (0.44) | LMNAMEN1KMT2AMAPK1POLB | |
| SCHEMBL1691128 | 0.81 | SMN1; SMN2 (0.42) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL1691141 | 0.81 | CYP4F2 (0.41) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL19325450 | 0.80 | OPRM1 (0.47) | OPRM1SLC22A1SLC6A4ADRA1AOPRD1 | |
| SCHEMBL22857099 | 0.80 | LMNA (0.40) | LMNAMEN1KMT2AMAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10441581-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2019-10-15 | — | — | US | disclosed |
| US-20180133207-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10441581-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | OPRM1 3497/4885SLC22A1 3801/4885SLC6A4 3586/4885 |
| US-20180133207-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | OPRM1 3497/4885SLC22A1 3801/4885SLC6A4 3586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.