Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | PTPRC | P08575 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2552269 | 0.98 | FOLH1 (0.53) | FOLH1TP53HTTFFAR1FFAR4 | |
| SCHEMBL3995720 | 0.85 | TSHR (0.50) | TP53FFAR1FFAR4AKR1B1USP2 | |
| SCHEMBL4430140 | 0.85 | NPC1 (0.52) | FOLH1TP53HTTUSP2ALOX5 | |
| SCHEMBL1368181 | 0.84 | TP53 (0.63) | FOLH1TP53HTTNR4A2PTPRC | |
| SCHEMBL10689361 | 0.84 | FFAR1 (0.71) | FFAR1FFAR4AKR1B1 | |
| SCHEMBL5989548 | 0.84 | RXRA (0.59) | FOLH1TP53HTTFFAR1FFAR4 | |
| SCHEMBL11618778 | 0.83 | CFD (0.55) | FOLH1TP53HTTFFAR1NR4A2 | |
| SCHEMBL13870541 | 0.82 | FFAR1 (0.56) | FOLH1TP53HTTFFAR1FFAR4 | |
| SCHEMBL28141293 | 0.82 | AKR1B1 (0.58) | HTTFFAR1FFAR4AKR1B1PTPRC | |
| SCHEMBL11621301 | 0.82 | FFAR1 (0.60) | FFAR1FFAR4AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4816591-A | 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives | AMERICAN HOECHST CORPORATION (US) | 1989-03-28 | — | — | US | disclosed |
| US-4585788-A | 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives | AMERICAN HOECHST CORPORATION (US) | 1986-04-29 | — | — | US | disclosed |