Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8037879 | 0.84 | POLB (0.61) | LMNAGAAPOLBMAPTPKM | |
| SCHEMBL384743 | 0.82 | GAA (0.57) | LMNACA2GAAPOLBMAPT | |
| SCHEMBL32689435 | 0.82 | ELANE (0.51) | LMNACA2ELANE | |
| SCHEMBL28818548 | 0.81 | ESR1 (0.56) | LMNACA2ELANE | |
| SCHEMBL11489461 | 0.81 | GAA (0.55) | LMNACA2GAAPOLBMAPT | |
| SCHEMBL11531056 | 0.81 | LMNA (0.53) | LMNAGAAPOLBMAPTPKM | |
| SCHEMBL1849340 | 0.81 | LMNA (0.53) | LMNAGAAPOLBMAPTPKM | |
| SCHEMBL24819498 | 0.80 | LMNA (0.69) | LMNAGAAPOLBMAPT | |
| SCHEMBL29833587 | 0.80 | LMNA (0.69) | LMNACA2GAAPOLBMAPT | |
| SCHEMBL1067193 | 0.80 | HTT (0.63) | CA2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4855314-A | VASOCONTRICTORS, TREATMENT OF MIGRAINES, 3-(AMINO-ETHYL)-5-(PHENYL(ALKYL)-CARBONYL OR SULFONYL-AMINOALKYL SUBSTITUTED | GLAXO GROUP LIMITED (GB) | 1989-08-08 | — | — | US | disclosed |
| EP-0240096-A1 | Indole derivatives having a selective vasoconstrictor activity | GLAXO GROUP LIMITED (GB) | 1987-10-07 | — | — | EP | disclosed |
| US-4297489-A | CEPHALOSPORINS | BRISTOL-MYERS COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| US-4133808-A | 4-(Formylthio)azetidinones and ozonization process therefor | ELI LILLY AND COMPANY (US) | 1979-01-09 | — | — | US | disclosed |
| US-4048157-A | 4(Formylthio)-azetidin-2-ones and ozonization process therefor | ELI LILLY AND COMPANY (US) | 1977-09-13 | — | — | US | disclosed |