Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LHCGR | P22888 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6545035 | 0.81 | CYP3A4 (0.48) | SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL11447599 | 0.73 | CYP3A4 (0.46) | TSHRSMN1; SMN2RECQLKDM4EMAPT | |
| SCHEMBL9151971 | 0.73 | CYP2D6 (0.61) | SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL11757293 | 0.73 | CYP2D6 (0.61) | SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL11465395 | 0.72 | CYP3A4 (0.45) | TSHRSMN1; SMN2RECQLMEN1KMT2A | |
| SCHEMBL11755929 | 0.70 | HSD11B1 (0.46) | SMN1; SMN2TP53 | |
| SCHEMBL19427415 | 0.69 | CYP3A4 (0.49) | SMN1; SMN2TP53MEN1KMT2AKDM4E | |
| SCHEMBL985851 | 0.67 | MTNR1B (0.56) | TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL998666 | 0.67 | ABCG2 (0.57) | SMN1; SMN2TP53ABCB1ABCG2KMT2A | |
| SCHEMBL23397304 | 0.66 | ALDH1A1 (0.51) | POLBMEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4857648-A | Isoquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 1989-08-15 | — | — | US | claimed |