Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10567151 | 0.90 | MAPK1 (0.39) | LMNAMAPK1TDP1MAPTNPSR1 | |
| SCHEMBL10565931 | 0.85 | ALDH1A1 (0.43) | LMNAMAPTTP53KMT2AALDH1A1 | |
| SCHEMBL10567299 | 0.84 | MAPT (0.38) | LMNAMAPK1TDP1MAPTNPSR1 | |
| SCHEMBL10568823 | 0.83 | MAPT (0.36) | LMNAMAPK1TDP1MAPTNPSR1 | |
| SCHEMBL9830264 | 0.82 | MAPT (0.41) | LMNAMAPK1TDP1MAPTNPSR1 | |
| SCHEMBL10477979 | 0.82 | MAPT (0.47) | LMNAMAPK1MAPTL3MBTL1KMT2A | |
| SCHEMBL9835169 | 0.81 | RECQL (0.43) | LMNAMAPK1TDP1MAPTNPSR1 | |
| SCHEMBL10563184 | 0.81 | PGR (0.35) | LMNAMAPK1MAPTKMT2AALDH1A1 | |
| SCHEMBL10569569 | 0.80 | POLB (0.35) | LMNAMAPK1TDP1MAPTNPSR1 | |
| SCHEMBL9831567 | 0.79 | MAPT (0.52) | LMNAMAPTNPSR1TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4835280-A | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| US-4695567-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-09-22 | — | — | US | disclosed |
| EP-0189103-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1986-07-30 | — | — | EP | disclosed |