Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GALR2 | O43603 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10477979 | 0.84 | MAPT (0.47) | L3MBTL1MAPTALDH1A1NPC1PKM | |
| SCHEMBL10567299 | 0.83 | MAPT (0.38) | RECQLL3MBTL1MAPTALDH1A1NPC1 | |
| SCHEMBL9830264 | 0.83 | MAPT (0.41) | RECQLMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL10568792 | 0.81 | LMNA (0.37) | RECQLL3MBTL1MAPTALDH1A1NPC1 | |
| SCHEMBL10567151 | 0.81 | MAPK1 (0.39) | RECQLL3MBTL1MAPTALDH1A1NPC1 | |
| SCHEMBL10565931 | 0.81 | ALDH1A1 (0.43) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL9831103 | 0.81 | MAPT (0.43) | MAPTALDH1A1NPC1LMNANPSR1 | |
| SCHEMBL27671305 | 0.81 | MAPT (0.38) | L3MBTL1MAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL10568823 | 0.80 | MAPT (0.36) | RECQLL3MBTL1MAPTKDM4EALDH1A1 | |
| SCHEMBL9831567 | 0.80 | MAPT (0.52) | MAPTKDM4EALDH1A1NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214592-B1 | PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE PRODUCTS | Roche Diagnostics GmbH (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4730003-A | Tricyclic compounds for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1988-03-08 | — | — | US | disclosed |
| EP-0214592-A2 | Pyrrolobenzimidazoles, process for their preparation and medicaments containing these products | Roche Diagnostics GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |