Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | JAK1 | P23458 | 2/20 | 0.50 |
| ▸ | TYK2 | P29597 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714113 | 0.81 | TDO2 (0.50) | ADRA2AKMT2AMEN1HTTLMNA | |
| SCHEMBL9631014 | 0.80 | ALDH1A1 (0.69) | HTTLMNAMAPK1ALDH1A1GAA | |
| SCHEMBL11217909 | 0.77 | GAA (0.54) | HTTMAPK1ALDH1A1GAAALOX15 | |
| SCHEMBL5545978 | 0.77 | ALDH1A1 (0.46) | HTTMAPK1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL5640255 | 0.76 | KMT2A (0.78) | JAK2JAK1TYK2KMT2AMEN1 | |
| SCHEMBL10836320 | 0.76 | GRIK1 (0.59) | JAK2JAK1TYK2KMT2AMEN1 | |
| SCHEMBL10571549 | 0.76 | ADRA2A (0.68) | JAK2JAK1TYK2ADRA2AKMT2A | |
| SCHEMBL10570649 | 0.74 | KMT2A (0.61) | ADRA2AKMT2AMEN1LMNAMAPK1 | |
| SCHEMBL9223214 | 0.73 | ALDH1A1 (0.47) | KMT2AMEN1HTTMAPK1ALDH1A1 | |
| SCHEMBL25168951 | 0.73 | ADRA2A (0.58) | ADRA2AKMT2AMEN1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4855308-A | Method of treating senile cognitive decline with N'-substituted aminopyridine adrenergic agents | WARNER-LAMBERT COMPANY (US) | 1989-08-08 | — | — | US | claimed |
| US-4855308-A | Method of treating senile cognitive decline with N'-substituted aminopyridine adrenergic agents | WARNER-LAMBERT COMPANY (US) | 1989-08-08 | — | — | US | disclosed |