Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | HTR1D | P28221 | 10/20 | 0.62 |
| ▸ | HTR1B | P28222 | 8/20 | 0.62 |
| ▸ | HTR1A | P08908 | 7/20 | 0.62 |
| ▸ | HTR2A | P28223 | 4/20 | 0.56 |
| ▸ | HTR2C | P28335 | 3/20 | 0.56 |
| ▸ | HTR2B | P41595 | 3/20 | 0.56 |
| ▸ | HTR1E | P28566 | 2/20 | 0.56 |
| ▸ | HTR1F | P30939 | 2/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | HTR3A | P46098 | 2/20 | 0.56 |
| ▸ | HTR5A | P47898 | 2/20 | 0.56 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784266 | 0.93 | HTR1A (0.71) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| Oxalic Acid SCHEMBL8868424 | 0.82 | KMT2A (0.64) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL9805227 | 0.81 | HTR1D (0.67) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| Bufotenine SCHEMBL5832731 | 0.80 | HTR1A (0.86) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| Oxalic Acid SCHEMBL9800367 | 0.80 | KMT2A (0.60) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| Oxalic Acid SCHEMBL10695674 | 0.80 | HTR1A (0.61) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| Oxalic Acid SCHEMBL10693370 | 0.79 | SLC6A4 (0.71) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| Oxalic Acid SCHEMBL9805661 | 0.79 | SLC6A4 (0.71) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL1750326 | 0.79 | HTR1A (0.76) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| Oxalic Acid SCHEMBL10691878 | 0.78 | HTR1A (0.70) | KMT2AHTR1DHTR1BHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4855314-A | VASOCONTRICTORS, TREATMENT OF MIGRAINES, 3-(AMINO-ETHYL)-5-(PHENYL(ALKYL)-CARBONYL OR SULFONYL-AMINOALKYL SUBSTITUTED | GLAXO GROUP LIMITED (GB) | 1989-08-08 | — | — | US | disclosed |
| EP-0240096-A1 | Indole derivatives having a selective vasoconstrictor activity | GLAXO GROUP LIMITED (GB) | 1987-10-07 | — | — | EP | disclosed |