Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.71 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | HTR1A | P08908 | 6/20 | 0.63 |
| ▸ | HTR2A | P28223 | 4/20 | 0.63 |
| ▸ | HTR2C | P28335 | 4/20 | 0.63 |
| ▸ | HTR1D | P28221 | 10/20 | 0.62 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.60 |
| ▸ | HTR1B | P28222 | 8/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.59 |
| ▸ | HTR1E | P28566 | 3/20 | 0.56 |
| ▸ | HTR7 | P34969 | 3/20 | 0.56 |
| ▸ | HTR2B | P41595 | 3/20 | 0.56 |
| ▸ | HTR5A | P47898 | 3/20 | 0.56 |
| ▸ | HTR6 | P50406 | 3/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.56 |
| ▸ | HTR3B | O95264 | 2/20 | 0.56 |
| ▸ | HTR1F | P30939 | 2/20 | 0.56 |
| ▸ | HTR3A | P46098 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29471382 | 0.92 | SLC6A4 (0.83) | SLC6A4HTR1AHTR2AHTR2CHTR1D | |
| SCHEMBL517473 | 0.92 | SLC6A4 (0.83) | SLC6A4HTR1AHTR2AHTR2CHTR1D | |
| Oxalic Acid SCHEMBL8870089 | 0.87 | KMT2A (0.73) | SLC6A4KMT2AHTR1AHTR2AHTR2C | |
| Bufotenine SCHEMBL5832731 | 0.85 | HTR1A (0.86) | SLC6A4KMT2AHTR1AHTR2AHTR2C | |
| Oxalic Acid SCHEMBL9805661 | 0.84 | SLC6A4 (0.71) | SLC6A4KMT2AHTR1AHTR2AHTR2C | |
| SCHEMBL3377485 | 0.83 | SLC6A4 (1.00) | SLC6A4HTR1AHTR2AHTR2CHTR1D | |
| Mebufotenin SCHEMBL7205139 | 0.82 | KMT2A (1.00) | SLC6A4KMT2AHTR1AHTR2AHTR2C | |
| SCHEMBL14631651 | 0.82 | HTR2A (0.59) | SLC6A4KMT2AHTR1AHTR2AHTR2C | |
| SCHEMBL8785730 | 0.81 | HTR7 (0.68) | SLC6A4KMT2AHTR1AHTR2AHTR2C | |
| SCHEMBL18824168 | 0.80 | HTR2A (0.68) | SLC6A4HTR1AHTR2AHTR2CHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4785016-A | VASOCONSTRICTION, MIGRAINES ALKANEAMINO, ALKANE SULFONAMIDE INDOLES | GLAXO GROUP LIMITED (GB) | 1988-11-15 | — | — | US | disclosed |