Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.66 |
| ▸ | MAOA | P21397 | 6/20 | 0.56 |
| ▸ | MAOB | P27338 | 5/20 | 0.56 |
| ▸ | DRD4 | P21917 | 7/20 | 0.54 |
| ▸ | DRD3 | P35462 | 7/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10668197 | 0.88 | DRD2 (0.66) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL10570662 | 0.88 | DRD2 (0.66) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL23097595 | 0.83 | DRD2 (0.81) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL10571607 | 0.82 | DRD2 (0.94) | DRD2MAOAMAOBDRD4DRD3 | |
| Hydrochloric Acid SCHEMBL10572620 | 0.82 | DRD2 (0.92) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL11270104 | 0.81 | HTR1A (0.56) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL10571057 | 0.80 | DRD2 (0.75) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL10572070 | 0.80 | DRD2 (0.55) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL10571753 | 0.80 | DRD2 (0.85) | DRD2MAOAMAOBDRD4DRD3 | |
| SCHEMBL10665990 | 0.80 | DRD2 (1.00) | DRD2MAOAMAOBDRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824840-A | ANTIHISTAMINES, NERVOUS SYSTEM CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| US-4734416-A | ANTIHISTAMINES, CENTRAL NERVOUS SYSTEM CONTROLLING ACTION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |