Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | FPR1 | P21462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14482170 | 0.86 | MEN1 (0.60) | RAB9AMAPTNPSR1PDE4DNPC1 | |
| SCHEMBL10572038 | 0.85 | HPGD (0.67) | HPGDMAPTNPSR1NPC1MEN1 | |
| SCHEMBL28040015 | 0.85 | HPGD (0.50) | HPGDRAB9AMAPTNPSR1NPC1 | |
| SCHEMBL10577265 | 0.85 | MEN1 (0.51) | RAB9AMAPTNPSR1PDE4DNPC1 | |
| SCHEMBL15153224 | 0.81 | RAB9A (0.74) | HPGDRAB9AMAPTNPSR1PDE4D | |
| SCHEMBL16500084 | 0.79 | TSHR (0.43) | HPGDRAB9AMAPTNPSR1PDE4D | |
| SCHEMBL14553211 | 0.78 | MEN1 (0.75) | HPGDRAB9AMAPTNPSR1PDE4D | |
| SCHEMBL15153205 | 0.78 | KMT2A (0.56) | HPGDMAPTNPSR1MEN1KMT2A | |
| SCHEMBL12264899 | 0.77 | PDE4D (0.59) | HPGDRAB9AMAPTNPSR1PDE4D | |
| SCHEMBL15153248 | 0.75 | MEN1 (0.53) | HPGDRAB9AMAPTNPSR1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552895-B1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | Westfälische Wilhelms Universität Münster (DE) | 2015-02-25 | — | — | EP | disclosed |
| US-8716485-B2 | Pyrazole synthesis by coupling of carboxylic acid derivatives and enamines | WESTFÄLISHE WILHELMS-UNIVERSITÄT MÜNSTER (DE) | 2014-05-06 | — | — | US | disclosed |
| US-8716485-B2 | Pyrazole synthesis by coupling of carboxylic acid derivatives and enamines | WESTFÄLISHE WILHELMS-UNIVERSITÄT MÜNSTER (DE) | 2014-05-06 | — | — | US | disclosed |
| US-20130012715-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | WESTFAELISCHE WILHELMS UNIVERSITAET MUENSTER (DE) | 2013-01-10 | — | — | US | disclosed |
| US-20130012715-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | WESTFAELISCHE WILHELMS UNIVERSITAET MUENSTER (DE) | 2013-01-10 | — | — | US | disclosed |
| WO-2011120861-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | WESTFÄLISHE WILHELMS-UNIVERSITÄT MÜNSTER (DE) | 2011-10-06 | — | — | WO | disclosed |
| US-4868198-A | ARTHROPODICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1989-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012715-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | PC, ENO1, PDK2 | HPGD 241/4885RAB9A 2706/4885MAPT 2522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.