Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10575299 | 0.92 | METAP2 (0.40) | METAP2HDAC6 | |
| SCHEMBL10579195 | 0.83 | METAP1 (0.48) | METAP2NPC1RAB9AHDAC6 | |
| SCHEMBL10575330 | 0.83 | AURKA (0.41) | METAP2HDAC6 | |
| SCHEMBL10576840 | 0.82 | HDAC6 (0.36) | HDAC6 | |
| SCHEMBL10694085 | 0.81 | METAP2 (0.31) | METAP2HDAC6 | |
| SCHEMBL10573014 | 0.81 | METAP2 (0.31) | METAP2HDAC6 | |
| SCHEMBL10574691 | 0.81 | KDM4E (0.43) | NPC1RAB9AHDAC6 | |
| SCHEMBL10575751 | 0.80 | METAP2 (0.34) | METAP2HDAC6 | |
| SCHEMBL10695351 | 0.80 | METAP2 (0.54) | METAP2NPC1LMNAPKMRAB9A | |
| SCHEMBL10577392 | 0.80 | HDAC6 (0.30) | HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |