Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPSE | Q9Y251 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | MPL | P40238 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10574843 | 0.92 | HDAC6 (0.34) | HDAC6TP53MAPTSMN1; SMN2KDM4E | |
| SCHEMBL10576865 | 0.91 | HDAC6 (0.43) | HDAC6TP53MAPTSMN1; SMN2HPSE | |
| SCHEMBL10574912 | 0.89 | MITF (0.37) | HDAC6TP53MAPTSMN1; SMN2KDM4E | |
| SCHEMBL10577324 | 0.89 | DGAT1 (0.46) | HDAC6TP53MAPTSMN1; SMN2HPSE | |
| SCHEMBL10574691 | 0.88 | KDM4E (0.43) | HDAC6MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10577199 | 0.86 | AMY1A (0.47) | TP53MAPT | |
| SCHEMBL10578441 | 0.86 | HDAC6 (0.46) | HDAC6TP53MAPTSMN1; SMN2KDM4E | |
| SCHEMBL10580688 | 0.86 | HDAC6 (0.52) | HDAC6TP53MAPTSMN1; SMN2HPSE | |
| SCHEMBL10694085 | 0.86 | METAP2 (0.31) | HDAC6MPL | |
| SCHEMBL10574665 | 0.85 | NPBWR1 (0.47) | HDAC6TP53MAPTSMN1; SMN2HPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |