Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | AMY1A | P0DUB6 | 7/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10575621 | 0.93 | AMY1A (0.36) | PDE5APDE3BPDE3AAMY1A | |
| SCHEMBL10578728 | 0.87 | NR1I2 (0.34) | PDE5APDE3BPDE3AAMY1APDE2A | |
| SCHEMBL10574093 | 0.85 | AMY1A (0.43) | PDE5APDE3BPDE3AAMY1AKDM4E | |
| SCHEMBL10579306 | 0.85 | CDK4 (0.38) | PDE5APDE3BPDE3AAMY1AMEN1 | |
| SCHEMBL10580104 | 0.84 | PDE5A (0.45) | PDE5AAMY1ANPC1RAB9ASLC2A1 | |
| SCHEMBL10577353 | 0.84 | NPC1 (0.37) | PDE5APDE3BPDE3AAMY1APDE2A | |
| SCHEMBL10578096 | 0.82 | AMY1A (0.37) | PDE5APDE3BPDE3AAMY1APDE2A | |
| SCHEMBL10765920 | 0.81 | AMY1A (0.39) | PDE5APDE3BPDE3AAMY1APDE2A | |
| SCHEMBL10578739 | 0.80 | AMY1A (0.36) | PDE5APDE3BPDE3AAMY1A | |
| SCHEMBL10578360 | 0.79 | AMY1A (0.34) | AMY1AALDH1A1HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |