Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.45 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10580112 | 0.92 | PDE5A (0.47) | PDE5AAMY1AAURKASLC2A1HDAC6 | |
| SCHEMBL10574093 | 0.87 | AMY1A (0.43) | PDE5AAMY1ANPC1RAB9AFGFR1 | |
| SCHEMBL10577353 | 0.85 | NPC1 (0.37) | PDE5AAMY1ASLC2A1NPC1RAB9A | |
| SCHEMBL10572968 | 0.85 | NPC1 (0.35) | AMY1ANPC1RAB9A | |
| SCHEMBL10579306 | 0.85 | CDK4 (0.38) | PDE5AAMY1ANPC1RAB9A | |
| SCHEMBL10575990 | 0.85 | NR1I2 (0.42) | AMY1A | |
| SCHEMBL10575604 | 0.84 | PDE5A (0.34) | PDE5AAMY1ASLC2A1NPC1RAB9A | |
| SCHEMBL10576075 | 0.84 | ALOX5 (0.47) | AMY1APARP1HDAC6 | |
| SCHEMBL10577199 | 0.83 | AMY1A (0.47) | AMY1A | |
| SCHEMBL10578360 | 0.83 | AMY1A (0.34) | AMY1ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |