Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 12/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10574102 | 0.92 | AMY1A (0.50) | AMY1AADORA2BNR1I2PDE5APDE3B | |
| SCHEMBL10580104 | 0.87 | PDE5A (0.45) | AMY1AFGFR1PDE5ANPC1RAB9A | |
| SCHEMBL10577353 | 0.87 | NPC1 (0.37) | AMY1APDE5APDE3BPDE3ANPC1 | |
| SCHEMBL10579306 | 0.86 | CDK4 (0.38) | AMY1ANR1I2PDE5APDE3BPDE3A | |
| SCHEMBL10575604 | 0.85 | PDE5A (0.34) | AMY1APDE5APDE3BPDE3ANPC1 | |
| SCHEMBL10574074 | 0.84 | AMY1A (0.47) | AMY1AADORA2BFGFR1NR1I2 | |
| SCHEMBL10578691 | 0.83 | GUSB (0.43) | NPC1RAB9ATDP1KDM4EMEN1 | |
| SCHEMBL10578360 | 0.82 | AMY1A (0.34) | AMY1ANPC1RAB9A | |
| SCHEMBL10576075 | 0.81 | ALOX5 (0.47) | AMY1APOLBKDM4EMEN1MAPT | |
| SCHEMBL10572968 | 0.81 | NPC1 (0.35) | AMY1ANR1I2NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |