Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Miconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 12/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.98 |
| ▸ | LMNA | P02545 | 5/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.98 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.98 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.98 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.98 |
| ▸ | PGR | P06401 | 4/20 | 0.98 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.98 |
| ▸ | DRD2 | P14416 | 4/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.98 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.98 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R)-Miconazole SCHEMBL10575725 | 1.00 | IDO1 (0.98) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| Miconazole SCHEMBL13934598 | 0.99 | IDO1 (1.00) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| (R)-Miconazole SCHEMBL30594078 | 0.99 | IDO1 (1.00) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| Miconazole SCHEMBL2866 | 0.99 | IDO1 (1.00) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| (R)-Miconazole SCHEMBL2867 | 0.99 | IDO1 (1.00) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| Miconazole SCHEMBL7647866 | 0.99 | IDO1 (1.00) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| Miconazole SCHEMBL9662051 | 0.99 | IDO1 (1.00) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| Miconazole SCHEMBL64342 | 0.99 | IDO1 (1.00) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| (R)-Miconazole SCHEMBL3131763 | 0.98 | IDO1 (0.98) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| Miconazole SCHEMBL9479815 | 0.98 | IDO1 (0.98) | IDO1CYP2C9CYP3A4LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4803066-A | SYNERGISTIC MIXTURE OF AN IMIDAZOLE OR TRIAZOLE COMPOUND AND SILVER SULFADIAZINE | SMITH & NEPHEW ASSOCIATED COMPANIES P.L.C. (GB) | 1989-02-07 | — | — | US | disclosed |