Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (R)-Miconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 12/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 7/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 5/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 5/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 5/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 4/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 4/20 | 1.00 |
| ▸ | CYP17A1 | P05093 | 4/20 | 1.00 |
| ▸ | PGR | P06401 | 4/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 4/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 1.00 |
| ▸ | DRD2 | P14416 | 4/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 4/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 4/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 4/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Miconazole SCHEMBL9662051 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| (R)-Miconazole SCHEMBL30594078 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| Miconazole SCHEMBL64342 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| Miconazole SCHEMBL13934598 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| Miconazole SCHEMBL7647866 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| Miconazole SCHEMBL2866 | 1.00 | IDO1 (1.00) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| (R)-Miconazole SCHEMBL3131763 | 0.99 | IDO1 (0.98) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| (R)-Miconazole SCHEMBL10575725 | 0.99 | IDO1 (0.98) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| Miconazole SCHEMBL9479815 | 0.99 | IDO1 (0.98) | IDO1CYP2C9CYP3A4LMNACYP1A2 | |
| Miconazole SCHEMBL10575722 | 0.99 | IDO1 (0.98) | IDO1CYP2C9CYP3A4LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 55563 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026107113-A1 | MODIFIED CELLS FOR PROGRAMMING EXTRA ENVELOPED VIRUSES (EEVs) AND THEIR USE FOR PRODUCING THE EEVs, THE PROGRAMMED EEVs AND USES THEREOF | CALIDI BIOTHERAPEUTICS (NEVADA), INC. (US) | 2026-05-21 | — | — | WO | claimed |
| WO-2026106952-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | CDG CARE (US) | 2026-05-21 | — | — | WO | claimed |
| WO-2026105160-A1 | NOVEL AGROCHEMICAL COMPOSITION COMPRISING 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS AND USE THEREOF | PI INDUSTRIES LTD. (IN) | 2026-05-21 | — | — | WO | claimed |
| WO-2026102345-A1 | METHODS OF ADMINISTERING THE VOLTAGE-GATED POTASSIUM CHANNEL OPENER AZETUKALNER | XENON PHARMACEUTICALS INC. (CA) | 2026-05-15 | — | — | WO | claimed |
| US-20260124224-A1 | USE OF COMBINED COMPOSITION IN PREPARING DRUG FOR RESISTING FUNGAL AND BACTERIAL INFECTIONS | NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY (CN) | 2026-05-07 | — | — | US | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| US-20260115192-A1 | PHARMACEUTICAL COMPOSITIONS | SHENZHEN PHARMACIN CO LTD (CN) | 2026-04-30 | — | — | US | claimed |
| EP-3222270-B1 | COMPOSITIONS FOR MUCOSAL ADHESION AND USES THEREOF | BIONANOPLUS S L (ES) | 2026-04-29 | — | — | EP | claimed |
| US-20260102419-A1 | USE OF COMPOUNDS IN THE TREATMENT OF FUNGAL INFECTIONS | BASILEA PHARMACEUTICA INTERNATIONAL AG, ALLSCHWIL (CH) | 2026-04-16 | — | — | US | claimed |
| US-4427660-A | Formyl-methionyl chemotatic peptide antibiotic conjugates useful in treating infections | RESEARCH CORPORATION (US) | 1984-01-24 | — | — | US | claimed |
| EP-0098743-A1 | Phenyl alpha-acyloxyacetamide derivates and their therapeutic use | Yu, Ruey J., Dr. (US) | 1984-01-18 | — | — | EP | claimed |
| EP-0094329-A1 | Tanning process for rendering leathers mycostatic, antimycosic and antifungicidal, and articles produced thereby | Roux, Joel (FR) | 1983-11-16 | — | — | EP | claimed |
| EP-0053936-A2 | Surgical dressing | Johnson & Johnson Products Inc. (US) | 1982-06-16 | — | — | EP | claimed |
| US-4321257-A | Potentiated medicaments | JOHNSON & JOHNSON (US) | 1982-03-23 | — | — | US | claimed |
| US-4317447-A | Drug delivery system | ORTHO PHARMACEUTICAL CORPORATION (US) | 1982-03-02 | — | — | US | claimed |
| US-4315001-A | VINSION DEFECTS; UROGENITAL DISEASES | BLOUGH HERBERT A | 1982-02-09 | — | — | US | claimed |
| US-4294852-A | WATER, AN ALIPHATIC ALCOHOL AND AN ORGANIC ACID TO ADJUST THE PH OF THE VEHICLE | JOHNSON & JOHNSON (US) | 1981-10-13 | — | — | US | claimed |
| US-4197318-A | CYCLOHEXYL SUBSTITUTED ALKANOLS AS POTENTIATORS | JOHNSON & JOHNSON (US) | 1980-04-08 | — | — | US | claimed |
| US-4082881-A | STEROIDS, DERMATITIS | E. R. SQUIBB & SONS, INC. (US) | 1978-04-04 | — | — | US | claimed |