Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.55 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10575696 | 0.83 | AKR1B1 (0.54) | AKR1B1ITGA4NPC1POLB | |
| SCHEMBL11278773 | 0.81 | POLB (0.61) | NPC1POLBLMNA | |
| SCHEMBL3667328 | 0.70 | ITGA4 (0.50) | AKR1B1ITGA4 | |
| SCHEMBL10441170 | 0.69 | ALDH1A1 (0.50) | NPC1 | |
| SCHEMBL7854954 | 0.69 | POLB (0.53) | NPC1POLB | |
| SCHEMBL4543280 | 0.68 | NPC1 (0.43) | AKR1B1NPC1POLBLMNA | |
| SCHEMBL13241881 | 0.68 | POLB (0.63) | POLBLMNA | |
| SCHEMBL3885046 | 0.67 | ALDH1A1 (0.43) | NPC1 | |
| SCHEMBL6036357 | 0.67 | POLB (0.55) | NPC1POLB | |
| SCHEMBL1725500 | 0.67 | POLB (0.55) | NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853401-A | Spiro-hydantoins as aldose reductase inhibitors | G. D. SEARLE & CO. (US) | 1989-08-01 | — | — | US | disclosed |