Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 4/20 | 0.54 |
| ▸ | GSK3B | P49841 | 4/20 | 0.54 |
| ▸ | ELANE | P08246 | 4/20 | 0.46 |
| ▸ | CTSG | P08311 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | CTRC | Q99895 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10572898 | 0.90 | GSK3A (0.48) | GSK3AGSK3BELANECTSGCYP2C19 | |
| SCHEMBL10576467 | 0.83 | BACE1 (0.43) | GSK3AGSK3BELANECYP2C19KMT2A | |
| SCHEMBL10570089 | 0.73 | ALDH1A1 (0.42) | ELANEKMT2AMGLLNPSR1MEN1 | |
| SCHEMBL10604466 | 0.71 | CNR1 (0.35) | BACE1CNR1ALDH1A1 | |
| SCHEMBL10570645 | 0.71 | ALDH1A1 (0.48) | ELANEKMT2AMGLLMEN1BACE1 | |
| SCHEMBL338442 | 0.70 | GSK3A (1.00) | GSK3AGSK3BELANECTSGF2 | |
| SCHEMBL8199517 | 0.69 | CA9 (0.41) | GSK3AGSK3BELANECYP2C19BACE1 | |
| SCHEMBL10574135 | 0.68 | GSK3A (0.70) | GSK3AGSK3BELANECTSGF2 | |
| SCHEMBL27818048 | 0.65 | GSK3A (0.75) | GSK3AGSK3BELANECTSGF2 | |
| SCHEMBL15461433 | 0.65 | CNR1 (0.80) | CYP2C19KMT2ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4746738-A | SKIN THICKENERS | WELLA AKTIENGESELLSCHAFT (DE) | 1988-05-24 | — | — | US | claimed |
| EP-0116318-B1 | TETRAHYDRO-1,3-THIAZINE-2,4-DIONES, THEIR USE AND AGENTS CONTAINING THESE COMPOUNDS FOR THE TREATMENT OF THE SKIN | Wella Aktiengesellschaft (DE) | 1988-03-02 | — | — | EP | claimed |
| EP-0116318-A1 | Tetrahydro-1,3-thiazine-2,4-diones, their use and agents containing these compounds for the treatment of the skin | Wella Aktiengesellschaft (DE) | 1984-08-22 | — | — | EP | claimed |
| WO-1984003041-A1 | TETRAHYDRO-1,3-THIAZIN-2,4-DIONE, UTILIZATION THEREOF AND SKIN TREATING AGENTS CONTAINING SAID COMPOUND | WELLA AG (DE) | 1984-08-16 | — | — | WO | claimed |
| US-4883652-A | THICKEN EPIDERMIS, PROTECTIVE COATING, ANTIAGING | WELLA AKTIENGESELLSCHAFT (DE) | 1989-11-28 | — | — | US | disclosed |
| US-4746738-A | SKIN THICKENERS | WELLA AKTIENGESELLSCHAFT (DE) | 1988-05-24 | — | — | US | disclosed |
| EP-0116318-B1 | TETRAHYDRO-1,3-THIAZINE-2,4-DIONES, THEIR USE AND AGENTS CONTAINING THESE COMPOUNDS FOR THE TREATMENT OF THE SKIN | Wella Aktiengesellschaft (DE) | 1988-03-02 | — | — | EP | disclosed |
| EP-0116318-A1 | Tetrahydro-1,3-thiazine-2,4-diones, their use and agents containing these compounds for the treatment of the skin | Wella Aktiengesellschaft (DE) | 1984-08-22 | — | — | EP | disclosed |
| WO-1984003041-A1 | TETRAHYDRO-1,3-THIAZIN-2,4-DIONE, UTILIZATION THEREOF AND SKIN TREATING AGENTS CONTAINING SAID COMPOUND | WELLA AG (DE) | 1984-08-16 | — | — | WO | disclosed |