Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 5/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10570089 | 0.90 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2ELANEMEN1 | |
| SCHEMBL10576643 | 0.75 | BACE1 (0.39) | ALDH1A1LMNASMN1; SMN2CTSDBACE1 | |
| SCHEMBL10576456 | 0.71 | GSK3A (0.54) | ALDH1A1ELANEMEN1KMT2AMGLL | |
| SCHEMBL10604466 | 0.69 | CNR1 (0.35) | ALDH1A1SMN1; SMN2BACE1 | |
| SCHEMBL10576467 | 0.69 | BACE1 (0.43) | LMNAELANEMEN1KMT2ABACE1 | |
| SCHEMBL10575710 | 0.68 | ALDH1A1 (0.41) | ALDH1A1LMNASMN1; SMN2CTSDBACE1 | |
| SCHEMBL10607870 | 0.68 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL19694222 | 0.67 | ALDH1A1 (0.49) | ALDH1A1LMNASMN1; SMN2ELANEMEN1 | |
| SCHEMBL6293045 | 0.66 | MGLL (0.48) | ALDH1A1LMNASMN1; SMN2ELANEMEN1 | |
| SCHEMBL11608974 | 0.62 | MEN1 (0.62) | ALDH1A1LMNASMN1; SMN2ELANEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4746738-A | SKIN THICKENERS | WELLA AKTIENGESELLSCHAFT (DE) | 1988-05-24 | — | — | US | claimed |
| EP-0116318-B1 | TETRAHYDRO-1,3-THIAZINE-2,4-DIONES, THEIR USE AND AGENTS CONTAINING THESE COMPOUNDS FOR THE TREATMENT OF THE SKIN | Wella Aktiengesellschaft (DE) | 1988-03-02 | — | — | EP | claimed |
| EP-0116318-A1 | Tetrahydro-1,3-thiazine-2,4-diones, their use and agents containing these compounds for the treatment of the skin | Wella Aktiengesellschaft (DE) | 1984-08-22 | — | — | EP | claimed |
| WO-1984003041-A1 | TETRAHYDRO-1,3-THIAZIN-2,4-DIONE, UTILIZATION THEREOF AND SKIN TREATING AGENTS CONTAINING SAID COMPOUND | WELLA AG (DE) | 1984-08-16 | — | — | WO | claimed |
| US-4883652-A | THICKEN EPIDERMIS, PROTECTIVE COATING, ANTIAGING | WELLA AKTIENGESELLSCHAFT (DE) | 1989-11-28 | — | — | US | disclosed |
| US-4746738-A | SKIN THICKENERS | WELLA AKTIENGESELLSCHAFT (DE) | 1988-05-24 | — | — | US | disclosed |
| EP-0116318-B1 | TETRAHYDRO-1,3-THIAZINE-2,4-DIONES, THEIR USE AND AGENTS CONTAINING THESE COMPOUNDS FOR THE TREATMENT OF THE SKIN | Wella Aktiengesellschaft (DE) | 1988-03-02 | — | — | EP | disclosed |
| EP-0116318-A1 | Tetrahydro-1,3-thiazine-2,4-diones, their use and agents containing these compounds for the treatment of the skin | Wella Aktiengesellschaft (DE) | 1984-08-22 | — | — | EP | disclosed |