Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10579790 | 0.81 | ADRB2 (0.47) | GRIN2BKDM4EGAAMEN1KMT2A | |
| SCHEMBL10359739 | 0.81 | POLB (0.57) | GRIN2BALDH1A1TDP1POLBGAA | |
| SCHEMBL10677172 | 0.81 | JAK2 (0.47) | GRIN2BALDH1A1SMN1; SMN2POLBGAA | |
| SCHEMBL9513736 | 0.80 | POLB (0.49) | GRIN2BALDH1A1KDM4ETSHRHTT | |
| SCHEMBL9514727 | 0.78 | POLB (0.43) | GRIN2BALDH1A1KDM4ETSHRHTT | |
| SCHEMBL9514777 | 0.77 | CA1 (0.46) | GRIN2BALDH1A1KDM4ETSHRHTT | |
| SCHEMBL10581142 | 0.77 | GRIN2B (0.42) | GRIN2BALDH1A1KDM4ETSHRHTT | |
| SCHEMBL9515021 | 0.77 | NAMPT (0.51) | GRIN2BALDH1A1KDM4ETSHRHTT | |
| SCHEMBL10646175 | 0.76 | ALDH1A1 (0.56) | GRIN2BALDH1A1TSHRHTTMEN1 | |
| SCHEMBL9625464 | 0.76 | ALDH1A1 (0.56) | GRIN2BALDH1A1TSHRHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4806536-A | Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents | PFIZER, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0233051-A2 | Antiarrhythmic Agents | Pfizer Limited (GB) | 1987-08-19 | — | — | EP | disclosed |