Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.67 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | THPO | P40225 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10580014 | 1.00 | ADORA2A (0.67) | ADORA2AADORA2BADORA3TSHRPMP22 | |
| SCHEMBL1298953 | 0.89 | ADORA3 (0.74) | ADORA2AADORA2BADORA3TSHRPMP22 | |
| SCHEMBL10579771 | 0.87 | ADORA2A (0.62) | ADORA2AADORA2BADORA3TSHRPMP22 | |
| SCHEMBL9495200 | 0.86 | ADORA2A (0.73) | ADORA2AADORA2BADORA3TSHRPMP22 | |
| SCHEMBL30139992 | 0.81 | AHCY (0.68) | ADORA2AADORA2BADORA3TSHRADORA1 | |
| SCHEMBL30139993 | 0.81 | AHCY (0.68) | ADORA2AADORA2BADORA3TSHRADORA1 | |
| SCHEMBL11884228 | 0.81 | AHCY (0.53) | ADORA2AADORA2BADORA3TSHRADORA1 | |
| SCHEMBL11884247 | 0.81 | AHCY (0.53) | ADORA2AADORA2BADORA3TSHRADORA1 | |
| SCHEMBL4520798 | 0.81 | AHCY (0.68) | ADORA2AADORA2BADORA3TSHRADORA1 | |
| SCHEMBL4520806 | 0.81 | AHCY (0.68) | ADORA2AADORA2BADORA3TSHRADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4868160-A | Method of treating psychosis using N6 -substituted -5'-oxidized adenosine analogs | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4738954-A | HYPOTENSIVE AGENTS, ANALGESICS, NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0222330-A2 | N6-Substituted-5'-oxidized adenosine analogs | WARNER-LAMBERT COMPANY (US) | 1987-05-20 | — | — | EP | disclosed |