SCHEMBL105848

SCHEMBL105848

COC(Cl)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.50
KMT2A Q03164 2/20 0.41
HTR2A P28223 3/20 0.41
HRH1 P35367 3/20 0.41
EPHX1 P07099 1/20 0.39
THRB P10828 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
MEN1 O00255 1/20 0.38
LMNA P02545 3/20 0.38
DPP4 P27487 2/20 0.38
F2 P00734 1/20 0.38
CYP1A2 P05177 1/20 0.38
CHRM2 P08172 1/20 0.38
CHRM4 P08173 1/20 0.38
CHRM5 P08912 1/20 0.38
ADRA2A P08913 1/20 0.38
CYP2D6 P10635 1/20 0.38
CHRM1 P11229 1/20 0.38
ADRA2B P18089 1/20 0.38
CHRM3 P20309 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15974014 1.00 TSHR (0.50) TSHRKMT2AHTR2AHRH1EPHX1
SCHEMBL3780267 0.86 PTGS2 (0.44) EPHX1CYP1A2ALDH1A1SMN1; SMN2
SCHEMBL3774968 0.78 TSHR (0.55) TSHRHTR2AHRH1TDP1LMNA
SCHEMBL7915804 0.78 TSHR (0.55) TSHRHTR2AHRH1TDP1LMNA
SCHEMBL28852926 0.77 IDO1 (0.40) KMT2AMEN1LMNACYP2D6SLC6A4
SCHEMBL15277285 0.77 TSHR (0.48) TSHRKMT2AHTR2AHRH1EPHX1
SCHEMBL11021620 0.77 CHRNA7 (0.46) TSHRKMT2ATDP1MEN1LMNA
SCHEMBL11403506 0.77 AOC3 (0.50) TSHRKMT2ATDP1MEN1LMNA
SCHEMBL14685170 0.75 TSHR (0.46) TSHRKMT2AEPHX1THRBLMNA
SCHEMBL4810833 0.75 TDP1 (0.54) TSHRTHRBTDP1CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 980 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119842078-A Polysulfone resin, preparation method thereof and polymer product 深圳市沃特新材料股份有限公司 2025-04-18 CN claimed
CN-118439936-A Method for preparing anisic aldehyde by using p-methoxybenzyl chloride 山东新和成药业有限公司 2024-08-06 CN claimed
CN-111920958-B Esterase response type gene drug loading system and preparation method thereof 青岛大学 2022-07-05 CN claimed
CN-114105984-A Preparation method of indolizine corrosion inhibitor 中国石油大学(华东) 2022-03-01 CN claimed
CN-111920958-A Esterase response type gene drug loading system and preparation method thereof 青岛大学 2020-11-13 CN claimed
US-10633470-B2 Method of producing a conjugated diene polymer, a modified conjugated diene polymer, and a vinyl cis-polybutadiene composition UBE INDUSTRIES, LTD. (JP) 2020-04-28 US claimed
US-20190256628-A1 Method of Producing a Conjugated Diene Polymer, a Modified Conjugated Diene Polymer, and a Vinyl Cis-Polybutadiene Composition UBE INDUSTRIES, LTD. (JP) 2019-08-22 US claimed
CN-109232541-A Prolyl hydroxylase and histon deacetylase (HDAC) double inhibitor and its preparation method and application 中国医学科学院放射医学研究所 2019-01-18 CN claimed
CN-105646884-B A kind of polyhydroxy polycarboxylic siloxanes and wear-resisting super-hydrophobic coat and preparation method 中科院广州化学有限公司南雄材料生产基地 2018-07-06 CN claimed
CN-105481925-B A kind of preparation method of Austria's shellfish cholic acid and its intermediate 南京济群医药科技股份有限公司 2018-06-22 CN claimed
CN-101781301-B Method for preparing entecavir UNIV FUDAN 2013-04-10 CN claimed
CN-103038923-A Rechargeable battery, functional polymer, and method for synthesis thereof POLYTHIONE CO LTD 2013-04-10 CN claimed
CN-102993031-A Preparation process of aromatic polyoxyalkyl quaternary ammonium compound BEIJING SUNPU BIOCHEMISTRY TECHNOLOGY CO LTD 2013-03-27 CN claimed
CN-102477019-A Novel method for producing S-3-hydroxytetrahydrofuran SUZHOU CHIREACH BIOLOG MEDICAL TECHNOLOGY CO LTD 2012-05-30 CN claimed
CN-102477036-A Method for preparing Entecavir monohydrate SHANGHAI YONGHONG IND GROUP CHMEICAL TECHNOLOGY CO LTD 2012-05-30 CN claimed
CN-101182322-B Method for preparing antiviral drug of Entecavir FUJIAN COSUNTER PHARMACEUTICAL CO LTD 2011-04-06 CN claimed
CN-102002023-A Preparation method of entecavir intermediate Hunan ouya biology co ltd 2011-04-06 CN claimed
CN-101182322-A Method for preparing antiviral drug of Entecavir FUJIAN GUANGSHENG TANG PHARMAC (CN) 2008-05-21 CN claimed
US-4127526-A ANALGESIC VETERANS ADMINISTRATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY 1978-11-28 US claimed
US-4059610-A Process for preparing isocyanic acid derivatives KAO SOAP CO., LTD. (JA) 1977-11-22 US claimed