SCHEMBL7915804

SCHEMBL7915804

ClC(OOC(Cl)c1ccccc1)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.55
DPP4 P27487 2/20 0.41
F2 P00734 1/20 0.41
HTR2A P28223 4/20 0.39
HRH1 P35367 4/20 0.39
IDO1 P14902 3/20 0.38
TDO2 P48775 3/20 0.38
TAAR1 Q96RJ0 1/20 0.38
TDP1 Q9NUW8 1/20 0.37
CYP2D6 P10635 2/20 0.36
SRC P12931 1/20 0.36
IDO2 Q6ZQW0 1/20 0.35
LMNA P02545 1/20 0.35
CYP1A2 P05177 1/20 0.35
CHRM2 P08172 1/20 0.35
CHRM4 P08173 1/20 0.35
CHRM5 P08912 1/20 0.35
ADRA2A P08913 1/20 0.35
CHRM1 P11229 1/20 0.35
ADRA2B P18089 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3774968 0.82 TSHR (0.55) TSHRDPP4F2HTR2AHRH1
SCHEMBL13278769 0.78 TSHR (0.50) TSHRDPP4F2HTR2AHRH1
SCHEMBL11666583 0.78 TSHR (0.50) TSHRDPP4F2HTR2AHRH1
SCHEMBL6930355 0.78 IDO1 (0.50) TSHRDPP4F2IDO1TDO2
SCHEMBL105848 0.78 TSHR (0.50) TSHRDPP4F2HTR2AHRH1
SCHEMBL7099520 0.78 TSHR (0.50) TSHRDPP4F2HTR2AHRH1
SCHEMBL15974014 0.78 TSHR (0.50) TSHRDPP4F2HTR2AHRH1
SCHEMBL661908 0.78 CYP2D6 (0.40) TSHRF2TDP1CYP2D6SRC
SCHEMBL6157714 0.76 TSHR (0.48) TSHRDPP4F2ADRA2AADRA2B
SCHEMBL3683731 0.74 TSHR (0.52) TSHRIDO1TDO2TDP1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0116611-A1 PROSTHESES CONTACT LENSES AND POLYMERS THEREFOR CONTACT LENSES (MANUFACTURING) LIMITED (GB) 1984-08-29 EP claimed
WO-1984000968-A1 PROSTHESES CONTACT LENSES AND POLYMERS THEREFOR CONTACT LENS MFG LTD (GB) 1984-03-15 WO claimed
US-6207397-B1 PREPARING A MIXTURE CONTAINING SAID FIRST AND SECOND MOLECULES AND A TEST SAMPLE, WHEREIN SECOND MOLECULE BEARING A COVALENTLY LINKED FLUOROPHORE, IRRADIATING THE MIXTURE TO EXCITE FLUOROPHORE, MEASUREING DEGREE OF POLARIZATATION OF ARIAD PHARMACEUTICALS, INC. 2001-03-27 US disclosed
EP-0898709-A2 $i(IN VITRO) FLUORESCENCE POLARIZATION ASSAY ARIAD PHARMACEUTICALS, INC. (US) 1999-03-03 EP disclosed
EP-0806469-A2 An enhanced biodegradable vegetable oil grease The Lubrizol Corporation (US) 1997-11-12 EP disclosed
WO-1997039326-A2 IN VITRO FLUORESCENCE POLARIZATION ASSAY ARIAD PHARMACEUTICALS, INC. (US) 1997-10-23 WO disclosed
EP-0218385-B2 Thermally developable light-sensitive material KONISHIROKU PHOTO IND (JP) 1997-05-14 EP disclosed
EP-0283938-B1 SILVER HALIDE COLOR PHOTOGRAPHIC MATERIAL Fuji Photo Film Co., Ltd. (JP) 1992-08-26 EP disclosed
EP-0173584-B1 HEAT-DEVELOPABLE COLOR PHOTO-SENSITIVE MATERIAL KONICA CORPORATION (JP) 1990-03-07 EP disclosed
EP-0174177-B1 HEAT-DEVELOPABLE COLOR PHOTO-SENSITIVE MATERIAL KONICA CORPORATION (JP) 1989-11-29 EP disclosed
EP-0186494-B1 HEAT-DEVELOPABLE COLOR PHOTO-SENSITIVE MATERIAL KONICA CORPORATION (JP) 1989-08-09 EP disclosed
EP-0186494-A2 Heat-developable color photo-sensitive material KONICA CORPORATION (JP) 1986-07-02 EP disclosed
EP-0174177-A2 Heat-developable color photo-sensitive material KONICA CORPORATION (JP) 1986-03-12 EP disclosed
EP-0173584-A2 Heat-developable color photo-sensitive material KONICA CORPORATION (JP) 1986-03-05 EP disclosed
EP-0157639-A2 Heat-developable multilayered color photo-sensitive material KONICA CORPORATION (JP) 1985-10-09 EP disclosed
EP-0116611-A1 PROSTHESES CONTACT LENSES AND POLYMERS THEREFOR CONTACT LENSES (MANUFACTURING) LIMITED (GB) 1984-08-29 EP disclosed
WO-1984000968-A1 PROSTHESES CONTACT LENSES AND POLYMERS THEREFOR CONTACT LENS MFG LTD (GB) 1984-03-15 WO disclosed
US-4320044-A IRON SESQUIOXIDE OR FERROFERRIC OXIDE MIXTURES FOR FIREPROOFING TORAY SILICONE COMPANY, LTD. (JP) 1982-03-16 US disclosed
US-4155901-A COPOLYMERIZATION OF ACRYLONITRILE AND SYTRENE IN PRESENCE OF DIENE ELASTOMER SUBSTRATE, CONTROLLED CONTINUOUS ADDITION OF MONOMERS THE STANDARD OIL COMPANY (US) 1979-05-22 US disclosed
US-3931133-A Suspension polymerization process for ethylenic monomers AQUITAINE TOTAL ORGANICO (FR) 1976-01-06 US disclosed