Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL105848 | 1.00 | TSHR (0.50) | TSHRKMT2AHTR2AHRH1EPHX1 | |
| SCHEMBL3780267 | 0.86 | PTGS2 (0.44) | EPHX1CYP1A2ALDH1A1SMN1; SMN2 | |
| SCHEMBL3774968 | 0.78 | TSHR (0.55) | TSHRHTR2AHRH1TDP1LMNA | |
| SCHEMBL7915804 | 0.78 | TSHR (0.55) | TSHRHTR2AHRH1TDP1LMNA | |
| SCHEMBL28852926 | 0.77 | IDO1 (0.40) | KMT2AMEN1LMNACYP2D6SLC6A4 | |
| SCHEMBL15277285 | 0.77 | TSHR (0.48) | TSHRKMT2AHTR2AHRH1EPHX1 | |
| SCHEMBL11021620 | 0.77 | CHRNA7 (0.46) | TSHRKMT2ATDP1MEN1LMNA | |
| SCHEMBL11403506 | 0.77 | AOC3 (0.50) | TSHRKMT2ATDP1MEN1LMNA | |
| SCHEMBL14685170 | 0.75 | TSHR (0.46) | TSHRKMT2AEPHX1THRBLMNA | |
| SCHEMBL4810833 | 0.75 | TDP1 (0.54) | TSHRTHRBTDP1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2958897-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014130582-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2014-08-28 | — | — | WO | disclosed |