Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | AGER | Q15109 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL630973 | 0.75 | POLB (0.43) | POLBTDP1LMNASMN1; SMN2EGLN3 | |
| SCHEMBL27561186 | 0.74 | POLB (0.42) | POLBTDP1LMNASMN1; SMN2EGLN3 | |
| SCHEMBL9560914 | 0.72 | TDP1 (0.46) | POLBTDP1LMNASMN1; SMN2TNF | |
| SCHEMBL9460847 | 0.72 | POLB (0.40) | POLBTDP1LMNASMN1; SMN2EGLN3 | |
| SCHEMBL9236926 | 0.72 | TDP1 (0.42) | POLBTDP1LMNASMN1; SMN2TNF | |
| SCHEMBL636638 | 0.70 | CYP11B1 (0.50) | TDP1LMNASMN1; SMN2EGLN3TNF | |
| SCHEMBL3335253 | 0.70 | POLB (0.46) | POLBTDP1LMNASMN1; SMN2TNF | |
| SCHEMBL1618548 | 0.69 | TDP1 (0.48) | POLBTDP1LMNASMN1; SMN2TNF | |
| SCHEMBL15742426 | 0.69 | POLB (0.42) | POLBTDP1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL22475379 | 0.67 | TDP1 (0.46) | POLBTDP1LMNASMN1; SMN2TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4820708-A | ANTISECRETORY AGENTS; GASTROINTESTINAL DISORDERS | SMITH KLINE & FRENCH LABORATORIES (GB) | 1989-04-11 | — | — | US | disclosed |
| US-4777172-A | ANTIGASTRIC ACID SECRETORY AGENT | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-10-11 | — | — | US | disclosed |