Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9560914 | 0.79 | TDP1 (0.46) | TDP1LMNASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL636638 | 0.76 | CYP11B1 (0.50) | TDP1LMNASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL1618548 | 0.76 | TDP1 (0.48) | TDP1LMNASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL2794591 | 0.73 | TDP1 (0.46) | TDP1LMNASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL9092595 | 0.73 | TDP1 (0.46) | TDP1LMNASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL22475379 | 0.73 | TDP1 (0.46) | TDP1LMNASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL630973 | 0.73 | POLB (0.43) | TDP1LMNASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL10587534 | 0.72 | POLB (0.39) | TDP1LMNASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL2802532 | 0.71 | TDP1 (0.44) | TDP1LMNASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL326813 | 0.68 | TDP1 (0.63) | TDP1LMNASMN1; SMN2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0045200-A1 | Benzimidazoles and their pharmaceutical use | THE UPJOHN COMPANY (US) | 1982-02-03 | — | — | EP | claimed |
| WO-1996021662-A1 | THE USE OF HETEROCYCLIC COMPOUNDS AS ANTIOXIDANTS, RADICAL SCAVENGERS, Fe2+ COMPLEXING AGENTS, TISSUE- AND/OR NEUROPROTECTANTS | RISE FRODE (NO) | 1996-07-18 | — | — | WO | disclosed |
| EP-0218336-B1 | USE OF BENZYLSULFINYLBENZIMIDAZOLES AS CYTOPROTECTIVE AGENTS FOR THE GASTROINTESTINAL TRACT | NIPPON CHEMIPHAR CO., LTD. (JP) | 1991-12-18 | — | — | EP | disclosed |
| US-4824856-A | Method of protecting gastrointestinal tract | NIPPON CHEMIPHAR CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0218336-A2 | Use of benzylsulfinylbenzimidazoles as cytoprotective agents for the gastrointestinal tract | NIPPON CHEMIPHAR CO., LTD. (JP) | 1987-04-15 | — | — | EP | disclosed |
| EP-0130729-A2 | Alkylthio- and alkylsulfinyl-benzimidazole derivatives | THE UPJOHN COMPANY (US) | 1985-01-09 | — | — | EP | disclosed |
| EP-0045200-A1 | Benzimidazoles and their pharmaceutical use | THE UPJOHN COMPANY (US) | 1982-02-03 | — | — | EP | disclosed |