Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.64 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12930264 | 0.87 | CHRM5 (0.52) | TRPA1CHRM5CHRM1ALDH1A1ALDH3A1 | |
| SCHEMBL12930259 | 0.87 | CHRM5 (0.52) | TRPA1CHRM5CHRM1ALDH1A1ALDH3A1 | |
| SCHEMBL12930241 | 0.85 | TRPA1 (0.55) | TRPA1CHRM5CHRM1ALDH1A1ALDH3A1 | |
| SCHEMBL12930261 | 0.85 | CHRM5 (0.53) | TRPA1CHRM5CHRM1ALDH1A1ALDH3A1 | |
| SCHEMBL5001267 | 0.82 | CHRM5 (0.60) | TRPA1CHRM5CHRM1ALDH1A1ALDH3A1 | |
| SCHEMBL12930236 | 0.81 | TRPA1 (0.64) | TRPA1CHRM5ALDH1A1ALDH3A1HSD17B10 | |
| SCHEMBL6283885 | 0.80 | TRPA1 (0.46) | TRPA1CHRM1ALDH1A1ALDH3A1HSD17B10 | |
| SCHEMBL1061400 | 0.78 | TRPA1 (1.00) | TRPA1 | |
| SCHEMBL1061402 | 0.78 | TRPA1 (1.00) | TRPA1 | |
| SCHEMBL5001336 | 0.78 | CHRM5 (0.58) | CHRM5CHRM1ALDH1A1ALDH3A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009379-A1 | INDOLINONE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-01-13 | — | — | US | disclosed |
| US-20110009379-A1 | INDOLINONE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-01-13 | — | — | US | disclosed |
| EP-2261206-A1 | INDOLINONE COMPOUND | Astellas Pharma Inc. (JP) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009123080-A1 | INDOLINONE COMPOUND | アステラス製薬株式会社 (JP) | 2009-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009379-A1 | INDOLINONE COMPOUND | TRPA1, TRPV1, TRPV6 | TRPA1 1/4885CHRM5 318/4885CHRM1 320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.