SCHEMBL6283885

SCHEMBL6283885

CC(C)CN1C(=O)C(=O)c2cccc(-c3ccccc3)c21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.46
CASP3 P42574 3/20 0.44
ALDH1A1 P00352 9/20 0.43
MAPT P10636 6/20 0.43
KMT2A Q03164 4/20 0.43
MEN1 O00255 3/20 0.43
HSD17B10 Q99714 3/20 0.43
LMNA P02545 1/20 0.43
MAPK1 P28482 1/20 0.43
HPGD P15428 2/20 0.42
TP53 P04637 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
CES1 P23141 2/20 0.40
BCHE P06276 1/20 0.40
TGM2 P21980 1/20 0.40
ALDH2 P05091 1/20 0.40
CHRM1 P11229 1/20 0.40
ALDH3A1 P30838 1/20 0.40
L3MBTL1 Q9Y468 2/20 0.39
ALOX15 P16050 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12930236 0.80 TRPA1 (0.64) TRPA1CASP3ALDH1A1MAPTKMT2A
SCHEMBL1058865 0.80 TRPA1 (0.64) TRPA1CASP3ALDH1A1MAPTKMT2A
SCHEMBL6283990 0.78 ALDH1A1 (0.56) ALDH1A1MAPTKMT2AMEN1HSD17B10
SCHEMBL6283905 0.77 ALDH1A1 (0.62) ALDH1A1MAPTKMT2AMEN1HSD17B10
SCHEMBL12930202 0.76 CES1 (0.65) ALDH1A1KMT2AMEN1CES1BCHE
SCHEMBL6280422 0.75 CDC25A (0.63) ALDH1A1MAPTHSD17B10HPGDCES1
SCHEMBL6284050 0.75 CDC25A (0.63) ALDH1A1MAPTHSD17B10HPGDCES1
SCHEMBL6279195 0.75 CDC25A (0.63) ALDH1A1MAPTHSD17B10HPGDCES1
SCHEMBL6286569 0.75 CDC25A (0.63) ALDH1A1MAPTHSD17B10HPGDCES1
SCHEMBL6283021 0.75 CDC25A (0.63) ALDH1A1MAPTHSD17B10HPGDCES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6906090-B1 Compositions and methods for treating mycobacterial diseases ASTRAZENECA AB (SE) 2005-06-14 US claimed
EP-1058548-B1 THE USE OF ISATIN AND OXINDOLE DERIVATIVES IN THE PREPARATION OF A MEDICAMENT FOR USE IN THE TREATMENT OF MYCOBACTERIAL DISEASE ASTRAZENECA AB (SE) 2003-09-17 EP claimed
EP-1058548-A1 NEW USE AstraZeneca AB (SE) 2000-12-13 EP claimed
WO-1999044608-A1 NEW USE ASTRAZENECA AB (SE) 1999-09-10 WO claimed
US-6906090-B1 Compositions and methods for treating mycobacterial diseases ASTRAZENECA AB (SE) 2005-06-14 US disclosed
EP-1058548-B1 THE USE OF ISATIN AND OXINDOLE DERIVATIVES IN THE PREPARATION OF A MEDICAMENT FOR USE IN THE TREATMENT OF MYCOBACTERIAL DISEASE ASTRAZENECA AB (SE) 2003-09-17 EP disclosed
EP-0958322-B1 FILLING MATERIAL MWO GES ZUR HERSTELLUNG VON CH (DE) 2003-01-15 EP disclosed
EP-1058548-A1 NEW USE AstraZeneca AB (SE) 2000-12-13 EP disclosed
EP-0958322-A1 FILLING MATERIAL MWO Gesellschaft zur Herstellung von Chemisch-Technischen Produkten MbH (DE) 1999-11-24 EP disclosed
WO-1999044608-A1 NEW USE ASTRAZENECA AB (SE) 1999-09-10 WO disclosed
WO-1998034983-A1 FILLING MATERIAL MWO GESELLSCHAFT ZUR HERSTELLUNG VON CHEMISCH-TECHNISCHEN PRODUKTEN MBH (DE) 1998-08-13 WO disclosed